Ownership Submission

FORM 4

Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940

OMB APPROVAL

OMB Number:

3235-0287

Estimated average burden hours per response...

0.5

(Print or Type Responses)

1. Name and Address of Reporting Person ^*

Tactic Pharma LLC

2. Issuer Name and Ticker or Trading Symbol
Monopar Therapeutics [MNPR]

5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)

_____ Director	__X__ 10% Owner
_____ Officer (give title below)	_____ Other (specify below)

(Last)

(First)

(Middle)

C/O 1000 SKOKIE BLVD, STE 350

3. Date of Earliest Transaction (Month/Day/Year)
02/11/2021

(Street)

WILMETTE, IL 60091

4. If Amendment, Date Original Filed(Month/Day/Year)

6. Individual or Joint/Group Filing(Check Applicable Line)
___ Form filed by One Reporting Person
_X_ Form filed by More than One Reporting Person

(City)

(State)

(Zip)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned

1.Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	3. Transaction Code (Instr. 8)		4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
1.Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	Code	V	Amount	(A) or (D)	Price		6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
Common stock	02/11/2021⁽¹⁾		S		42,467	D	$ 13.3 ⁽³⁾	249,200	D ⁽²⁾
Common stock	02/11/2021⁽¹⁾		S		24,224	D	$ 14.09 ⁽⁴⁾	224,976	D ⁽²⁾
Common stock	02/11/2021⁽¹⁾		S		29,996	D	$ 15.12 ⁽⁵⁾	194,980	D ⁽²⁾
Common stock	02/11/2021⁽¹⁾		S		16,384	D	$ 16.44 ⁽⁶⁾	178,596	D ⁽²⁾
Common stock	02/11/2021⁽¹⁾		S		11,929	D	$ 16.9 ⁽⁷⁾	166,667	D ⁽²⁾
Common stock								4,111,272.88	I ⁽²⁾ ⁽⁸⁾	See Footnotes

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
	Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB control number.		SEC 1474 (9-02)

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)

1. Title of Derivative Security
(Instr. 3)

2. Conversion or Exercise Price of Derivative Security

3. Transaction Date (Month/Day/Year)

3A. Deemed Execution Date, if any (Month/Day/Year)

4. Transaction Code
(Instr. 8)

5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4, and 5)

6. Date Exercisable and Expiration Date
(Month/Day/Year)

7. Title and Amount of Underlying Securities
(Instr. 3 and 4)

8. Price of Derivative Security
(Instr. 5)

9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 4)

10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4)

11. Nature of Indirect Beneficial Ownership
(Instr. 4)

Code

(A)

(D)

Date Exercisable

Expiration Date

Title

Amount or Number of Shares

Reporting Owners

Reporting Owner Name / Address	Relationships
Reporting Owner Name / Address	Director	10% Owner	Officer	Other
Tactic Pharma LLC C/O 1000 SKOKIE BLVD, STE 350 WILMETTE, IL 60091		X
Mazar Andrew Paul C/O 1000 SKOKIE BLVD, STE 350 WILMETTE, IL 60091	X		Chief Scientific Officer
Robinson Chandler C/O 1000 SKOKIE BLVD, STE 350 WILMETTE, IL 60091	X		Chief Executive Officer
O'Halloran Thomas V. C/O 1000 SKOKIE BLVD, STE 350 WILMETTE, IL 60091		X
Brown Michael J C/O 1000 SKOKIE BLVD STE 350 WILMETTE, IL 60091	X

Signatures

/s/ Kim R. Tsuchimoto, Attorney-in-fact		02/16/2021
^**Signature of Reporting Person		Date
/s/ Kim R. Tsuchimoto, Attorney-in-fact		02/16/2021
^**Signature of Reporting Person		Date
/s/Kim R. Tsuchimoto, Attorney-in-fact		02/16/2021
^**Signature of Reporting Person		Date
/s/Kim R. Tsuchimoto, Attorney-in-fact		02/16/2021
^**Signature of Reporting Person		Date
/s/ Kim R. Tsuchimoto, Attorney-in-fact		02/16/2021
^**Signature of Reporting Person		Date

Explanation of Responses:

*	If the form is filed by more than one reporting person, see Instruction 4(b)(v).
**	Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1)	Trade made pursuant to a 10b5-1 plan executed on November 24, 2020.
(2)	This Form 4 is being filed on behalf of Tactic Pharma LLC, an Illinois limited liability company ("Tactic"), and its managers, Andrew P. Mazar, Chandler D. Robinson, Michael J. Brown, and Thomas V. O'Halloran (collectively, the "Reporting Persons"). The managers collectively have voting control over the securities described herein. The managers each disclaim ownership of the shares of common stock owned by Tactic, except to the extent of their pecuniary interest therein.
(3)	The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $12.66 to $13.65, inclusive. The reporting person undertakes to provide to Monopar Therapeutics Inc., any security holder of Monopar Therapeutics Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnotes (3) through (7) to this Form 4.
(4)	The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $13.66 to $14.54, inclusive.
(5)	The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $14.76 to $15.75, inclusive.
(6)	The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $15.77 to $16.76, inclusive.
(7)	The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $16.77 to $17.01, inclusive.
(8)	Tactic shares voting and investment power over 4,111,272.88 of the shares of common stock held by TacticGem LLC.

Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.

Potential persons who are to respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB number.