Annual report pursuant to Section 13 and 15(d)


Cover - USD ($)
12 Months Ended
Dec. 31, 2021
Mar. 11, 2022
Jun. 30, 2021
Cover [Abstract]      
Entity Registrant Name MONOPAR THERAPEUTICS INC.    
Entity Central Index Key 0001645469    
Document Type 10-K    
Amendment Flag false    
Entity Voluntary Filers No    
Current Fiscal Year End Date --12-31    
Entity Well Known Seasoned Issuer No    
Entity Small Business true    
Entity Shell Company false    
Entity Emerging Growth Company true    
Entity Current Reporting Status Yes    
Document Period End Date Dec. 31, 2021    
Entity Filer Category Non-accelerated Filer    
Document Fiscal Period Focus FY    
Document Fiscal Year Focus 2021    
Entity Ex Transition Period true    
Entity Common Stock Shares Outstanding   12,604,514  
Entity Public Float     $ 25,238,039
Document Annual Report true    
Document Transition Report false    
Entity File Number 001-39070    
Entity Incorporation State Country Code DE    
Entity Interactive Data Current Yes    
Icfr Auditor Attestation Flag false    
Entity Tax Identification Number 32-0463781    
Entity Address Postal Zip Code 60091    
Entity Address Address Line 1 1000 Skokie Blvd.    
Entity Address Address Line 2 Suite 350    
Entity Address City Or Town Wilmette    
Entity Address State Or Province IL    
City Area Code 847    
Local Phone Number 388-0349    
Security 12b Title Common stock, $0.001 par value    
Trading Symbol MNPR    
Security Exchange Name NASDAQ    
Auditor Location Walnut Creek, California    
Auditor Name BPM LLP    
Auditor Firm Id 207